Immunohistochemical expression: Cytokeratins CK19, CK14, β-Catenin and Ki67 in Ameloblastoma and Odontogenic Keratocyst
DOI:
https://doi.org/10.21615/cesodon.33.2.8Keywords:
ameloblastoma, β-catenin, cytokeratin, immunohistochemicals, odontogenic keratocystsAbstract
Introduction and objective: Odontogenic tumors and cysts are lesions that occur in the jaws when derived from embryonic odontogenic tissue. Ameloblastoma is a benign tumor of epithelial origin, intraosseous, characterized by its expansion and local invasion. On the other hand, odontogenic keratocyst is a cystic, intraosseous and extraosseous lesion, with aggressive local destructive behavior and highly recurrent. to find the expression of the CK19, CK14, β-Catenin, Ki-67 proteins in the processed biopsies of odontogenic amaloblastomas and keratocysts during the 2015-2018 Department of Oral and Maxillofacial Pathology of the Faculty of Dentistry of the National University of Colombia. Materials and methods: Case series study where paraffin blocks were taken with histopathological diagnosis already confirmed ameloblastoma (9 blocks): CK19 / 14, Ki67, β-Catenin and odontogenic keratocyst (16 blocks): CK19 / 14, Ki67. Results: The average Ki67 in ameloblastoma and odontogenic keratocyst was 32% and 22%, respectively. For the ameloblastoma and the odontogenic keratocyst, CK19 / 14 was positive for all cases. Finally, β-Catenin marked intensely positive in all cases of ameloblastoma. Conclusions: These lesions can be diagnosed using only hematoxylin eosin, relying on immunohistochemical markers to corroborate the diagnosis or when you want to determine metastases in malignant lesions. The CK14 / 19 are odontogenic markers that determine the origin of the lesion, β-Catenin determines the aggressive behavior of the pathology and the Ki67 determines the behavior, prognosis and treatment of the present pathology.
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